Influence Of Bacterial Vaginosis On Conception And Miscarriage In The First Trimester

...Objectives: To assess whether bacterial vaginosis affects the rates of conception and miscarriage in the first trimester.
Design: Cohort study.
Setting: Assisted conception unit of a teaching hospital in Leeds.
Participants: 867 consecutive women undergoing in vitro fertilisation....

....Bacterial vaginosis does not affect conception rate

Bacterial vaginosis is associated with a two-fold risk of miscarriage in the first trimester

The increased miscarriage rate is equivalent to one extra miscarriage for every six pregnant women with bacterial vaginosis

The most likely cause of the miscarriages is due to pre-existing endometritis affecting implantation or early embryonic development, which could also affect naturally conceived pregnancies...

The highest relative risk of preterm birth was reported at 6.9 by Kurki et al.1 All the women were screened between 8 and 17 weeks of gestation, which is earlier than in other studies.

Hay et al3 and McGregor et al4 found an increased relative risk of 3.9 and 3.1 for miscarriage in the mid trimester, when bacterial vaginosis was diagnosed before 16 weeks of gestation..........

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